Which of the following medications is known to potentially cause drug-induced hepatitis?

Isoniazid (INH) is well-documented as a medication that can cause drug-induced hepatitis. This side effect is particularly concerning because it can lead to significant liver damage, especially in individuals who may have pre-existing liver conditions or those who consume alcohol. INH is used extensively in the treatment and prevention of tuberculosis, and the risk of liver toxicity necessitates regular monitoring of liver function tests during therapy. This hepatotoxic effect is dose-dependent but can also occur idiosyncratically in some patients.

While other medications listed have various side effects, they are not typically associated with drug-induced hepatitis to the extent seen with INH. For instance, ibuprofen can cause mild liver enzyme elevations but is more commonly associated with gastrointestinal issues. Metformin is primarily linked to lactic acidosis but is not a significant cause of hepatitis. Warfarin, an anticoagulant, can influence liver function tests but does not directly cause hepatitis in the same way that INH does. Thus, Isoniazid stands out as the medication with the clearest association with drug-induced hepatitis.