Which of the following factors can contribute to endometriosis?

Genetic predisposition plays a significant role in the development of endometriosis. Research has shown that women with a family history of endometriosis are more likely to develop the condition themselves, suggesting that genetic factors may influence susceptibility. Various studies have identified specific genetic variations that correlate with higher rates of endometriosis among relatives of affected individuals, reflecting a hereditary component of the disease.

While factors such as obesity, smoking, and age at menarche can potentially influence reproductive health and conditions affecting the female reproductive system, they are not as strongly connected to the pathogenesis of endometriosis as genetic predisposition. Obesity may have an indirect influence through hormonal pathways and inflammation, but its direct link to the etiology of endometriosis is less clear. Smoking has been associated with an increased risk for various reproductive issues but is not a major risk factor for endometriosis itself. The age at menarche could affect the overall hormonal milieu but does not have a strong established connection with the development of endometriosis compared to genetic factors. Therefore, genetic predisposition stands out as a primary contributor to endometriosis.