Which medication is known to cause drug-induced systemic lupus erythematosus (SLE)?

Isoniazid is known to be one of the medications that can induce drug-induced systemic lupus erythematosus (SLE). This reaction is part of a broader category of drug-induced lupus syndromes that can be triggered by certain medications.

Drug-induced lupus typically presents with symptoms similar to those of idiopathic SLE but usually resolves after discontinuing the offending agent. Isoniazid, commonly used for the treatment of tuberculosis, is recognized for its potential to cause an autoimmune-like reaction in predisposed individuals, which can lead to symptoms such as arthralgias, myalgias, fever, and serositis.

The mechanism by which isoniazid causes lupus involves alterations in the immune system, including changes in the formation of autoantibodies, particularly in individuals with a genetic predisposition. While other medications are associated with drug-induced lupus, isoniazid is one of the classic examples cited in medical literature.

This provides a clear understanding of the relationship between isoniazid and drug-induced SLE, differentiating it from other medications like acetaminophen, ibuprofen, or lisinopril, which are not commonly associated with this condition.