What is the primary therapy for polycystic ovary syndrome (PCOS)?

The primary therapy for polycystic ovary syndrome (PCOS) involves a combination of weight loss and the use of oral contraceptive pills (OCPs). This approach addresses the two most common issues faced by individuals with PCOS: insulin resistance and menstrual irregularities.

Weight loss is significant because even a modest reduction in body weight (around 5-10%) can lead to improvements in insulin sensitivity, ovulatory function, and hormonal balance. As many individuals with PCOS are overweight or obese, achieving weight loss can have profound effects on managing the symptoms.

Oral contraceptive pills help to regulate menstrual cycles, reduce hyperandrogenism (which can lead to symptoms such as hirsutism and acne), and protect the endometrial lining from unopposed estrogen. The combination of these two interventions not only supports weight management but also effectively manages the hormonal imbalances associated with PCOS.

While insulin therapy and metformin can be beneficial for improving insulin sensitivity, particularly in those with significant insulin resistance, these options are usually adjuncts rather than primary treatments. Thyroid hormone replacement is not related to the management of PCOS and would only be applicable if there were an underlying thyroid disorder. Therefore, the combination of weight loss and oral