What is the most common inherited cause of hypercoagulability?

The most common inherited cause of hypercoagulability is the Factor V Leiden mutation. This mutation involves a specific alteration in the factor V gene, which makes factor V resistant to inactivation by activated protein C. As a result, individuals with Factor V Leiden have an increased risk of developing venous thromboembolism, including deep vein thrombosis and pulmonary embolism.

The prevalence of Factor V Leiden in the general population and among patients with venous thromboembolism highlights its significance as the leading inherited cause of hypercoagulability. Inherited conditions such as Protein C deficiency and Antithrombin III deficiency are less common. Although both conditions contribute to an increased risk of thrombosis, they are not as frequently encountered as Factor V Leiden mutation. The prothrombin gene mutation does also contribute to hypercoagulability but has lower prevalence compared to Factor V Leiden, making it less significant as an inherited cause of this condition.

Understanding the implications of factor V Leiden is critical for both diagnosis and management of patients who present with thromboembolic disorders, emphasizing the importance of genetic screening and appropriate anticoagulation strategies in affected individuals.